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The healthy CNS has an extremely low level of immune surveillance with the almost complete absence of subsets of leukocytes including neutrophils, T cells and B cells, however changes to the BBB during diseases including multiple sclerosis MS, stroke, and neurodegenerative disorders can allow entry of immune cells into the CNS which is an important component of the pathogenesis of these diseases cialis cheapest online prices White J, Kearins O, Dodwell D, Horgan K, Hanby AM, Speirs V